A new trial at the University of Amsterdam found no evidence for the usefulness of high-dose baclofen in treating alcoholism when added to psychosocial treatments.
Recently, the drug received high visibility as a possible breakthrough treatment for alcohol dependence.
Recent trials have suggested high doses of the GABA-b agonist baclofen can be effective in the treatment of alcohol dependent patients.
A recent article Medical News Today noted that recent studie, coupled with individual patient testimonies, have given baclofen a high public profile, prompting the French authorities in 2014 to give permission to physicians to prescribe high doses baclofen for alcohol-dependent patients, pending results from ongoing randomized clinical trials.
Even before that permission, more than 200,000 persons had used baclofen "off label" in France alone. Baclofen is licenced for use as a skeletal muscle relaxant for spasms (spasticity).
Now researchers from the Netherlands have carried out the largest randomised controlled trial (RCT)...
Young adults with symptoms of alcohol dependence may see health effects late in life - even decades after conquering their problem drinking, according to a study in the Journal of Studies on Alcohol and Drugs.
A recent article in Medical News Today noted that researchers found that, of 664 U.S. male veterans, those who had symptoms of alcohol dependence for at least five years in young adulthood generally had poorer physical and mental health by the time they were in their 60s.
And that was true even if they'd gotten control over their drinking problems by the age of 30.
The new findings suggest that years of alcohol dependence during young adulthood result in silent but "permanent" injuries that, in later life, appear to result in serious health problems, according to Haber.
Young men with alcohol dependence are more likely to have health problems later in life, compared with their peers who do not drink, a new study suggests.
Researchers found young adult men with alcohol dependence had an average of three medical conditions when they reached their 60s, compared with two medical conditions for those who did not drink.
The study analyzed Vietnam-era veterans, according to HealthDay.
Men who had been heavy drinkers early in life were more likely to have health problems even if they had quit drinking for many years. The researchers said the results indicate there may be hidden mental or physical consequences of heavy drinking in young adulthood.
The findings appear in the Journal of Studies on Alcohol & Drugs.