The discovery of a gene variant associated with opioid addiction in African Americans may lead to personalized methadone treatment, according to HealthDay.
The gene variant helped identify African Americans who might need higher doses of methadone.
Patients receiving methadone treatment for opioid addiction vary widely in their dose requirements, the researchers note. Too high of a dose can cause sedation and dangerous breathing difficulties, while too low of a dose can lead to relapse.
“Opioid addiction has become a national epidemic, and improving the effectiveness of medical therapies has to be a priority,” study lead author Andrew Smith of Yale University said in a news release.
The same gene variant was also found to predict the morphine dose needed to achieve effective pain control in African American children undergoing surgery. The findings are published in the journal Molecular Psychiatry.
Dear Friend of NCADD ... It takes courage, determination and strength to avoid alcohol and drugs or to seek help and overcome addiction. We want to do everything in our power to provide the tools and support to help those on this journey. Without question, this is the most important journey of their lives and your support makes a huge difference in its outcome! On behalf of all those on the journey to recovery, and of all those waiting to start that journey, we thank you. Donate Now