NIH Announces Partnerships With Drug Companies to Create New Addiction Treatments

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The National Institutes of Health (NIH) will partner with drug companies to spur research on new treatments for opioid addiction and pain medications that are not addictive, according to The Wall Street Journal . In an article in the New England Journal of Medicine , NIH Director Francis S. Collins and Nora D. Volkow, Director of the National Institute on Drug Abuse, said the NIH will join with drug companies to launch an initiative in three scientific areas: developing better overdose-reversal and prevention interventions to reduce mortality, saving lives for future treatment and recovery; finding new, innovative medications and technologies to treat opioid addiction; and finding safe, effective, nonaddictive interventions to manage chronic pain. Collins and Volkow called for stronger versions of the opioid overdose antidote naloxone to counteract painkillers such as fentanyl and carfentanil, which are much more potent than heroin.
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Introducing a compound called CB1 PAM

Introducing a compound called CB1 PAM
The risks associated with the use of opioids and medical marijuana have fueled the search for safer, effective pain medications. It is known that opioids and medical marijuana are considered effective treatments for chronic pain, but the drugs carry significant risks. Andrea Hohmann, of Indiana University in Bloomington, and team believe they may have moved one step closer to a potential candidate: a compound called CB1 PAM. The researchers recently presented their findings at the Society for Neuroscience's 46th annual meeting, held in San Diego, CA. According to Medical News Today , the researchers used CB1 PAM and it’s use led to long-term pain relief in mice. Importantly, the article notes, the compound did not trigger the "high" associated with marijuana use, and unlike the marijuana compound THC and endocannabinoid breakdown inhibitors, CB1 PAM showed long-term efficacy for preventing pain. "Our studies show that we can maintain or preserve therapeutic...
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