Models of Alcoholism: Medical / Physiological Causes

Models of Alcoholism:  Medical / Physiological Causes

Models of Alcoholism: Medical / Physiological Causes

Medical Illness Model:

Near the end of the Second World War researchers and leaders in the recovery community jointly formulated the problem of uncontrolled drinking into what is now known as the Disease Model of alcoholism. This model postulates that, like medical illnesses, alcoholism--more specifically alcohol dependence, or addiction—can be diagnosed, its course observed, and its physical causes understood. Further, scientific trials can be undertaken to identify the best treatments for those who suffer from it. The diagnosis of Alcohol Dependence, in this model, rested on four symptoms: 1) a tolerance to alcohol in which a person needs to drink ever greater amounts to reach a desired effect, 2) withdrawal symptoms, such as "the shakes" and others, on stopping use, 3) the Loss of Control phenomenon in which affected persons lose the ability to control how much they drink at a sitting and thereby can no longer predict how much they will drink from one episode to the next, and 4) social or physical impairment resulting from combinations of the first three symptom categories1.

This model pictures a condition from which many alcohol dependent people emerge every year, and into which many others return. View as a disease, alcoholism takes on the characteristics of a remitting-relapsing illness with primary symptoms that direct us to brain functioning. And, because ethyl alcohol is a very small molecule with easy access to most parts of the body, moderate to heavy alcohol use often injures other organs, such as the liver and heart among others. Uncontrolled, or dependent, alcohol use also affects the social network setting of family as well as work activities, friendships, and legal involvement. Last, however, the Disease model brings with it the possibilities of treatment and of hope. At this date, effective medicinal agents against alcoholism are very few. But hope, that necessary ingredient for recovery, waxes strong in the illness model. In the words of the alcoholic patient quoted in the Part 2, "It is much easier to think of myself as an ill person working to become well, rather than a bad person trying to become good."

Genetic Models:

From the Disease model has come another, that of genetic influence. The observation that alcoholism often runs in families for many years meant that family cultures or mores determined who would become alcoholic and who would not. While it is clear that cultural and family life influences are very powerful, more recent studies have noted that an underlying genetic disposition may be at play in some genealogical lines2. If so, the evidence suggests a confluence of many gene effects rather than the dominant/recessive results of inheritance in Mendelian models of genetic death, as for example, in Huntington's Disease. Instead, the gene effects seem to have more to do with the vulnerability towards alcoholism. One form appears in those who have a genetically-based insensitivity to alcohol—an "inborn tolerance," and develop alcohol dependence at much higher rates than alcohol sensitive comparison groups. Another form may require a combination of gene influences and environment conditions to come together to result in alcohol-plus-multiple drug dependence, sometimes referred to as Type 2 or Type B alcoholics.

Unexpectedly, the news of gene involvement was greeted with enthusiasm among some quarters of the actively drinking alcoholic public: "Since alcoholism is genetic, we can't escape our genes and may as well keep drinking." As with older models however, the element of choice remains present in the sober periods between drinking episodes. As some of the other models suggest, healing from alcoholism remains an individual process.

Psychological Adaptation Models in Illness and Recovery:

Further modern research asks that we look at individuals and their abilities to adapt to the stresses of life. Careful observation has established that individual humans have the ability to adapt creatively to the painful thoughts and feelings of living and to do so in ways that connect us together rather than drive us apart3. This model of Mature human psychological adaptation, however, emphasizes that the brain function at its healthy best. Heavy, continuous use of alcohol carries often subtle, if severe, effects on the brain that are as yet poorly understood.

But we know they exist because of their effects in driving down the ability to adapt, from psychological Maturity to much more rigid Primitive mechanisms of coping, such as when an alcoholic "denies" that an obvious problem exists at all. This kind of Denial can occur in the actively drinking alcoholic who understands that resolving his or her ambivalence toward drinking is too painful to contemplate; therefore, a failure to perceive the problem seems preferable than facing it. So it is that the Adaptation model views the First of the Twelve Steps as addressing primitive Denial in coming to recognize that the individual's alcoholism exists. Progressing along the continuum of the Steps leads finally to the Twelfth: helping others who have the same problem. In the Psychological Adaptation model, this exemplifies the Mature mechanism of Altruism: selflessly helping others. The occurrence of brain healing as abstinence continues—along with the progression towards psychological maturity, whether viewed in the Psychological Adaptation or the Twelve Step models—suggests that brain recovery process are at work. We can only recognize their existence at this point, and need to understand their biology if we are to improve treatments in the Disease model.

Many Models, More Questions:

With this overview of the different model formulations of the problem of alcoholism and what to do about it, we are now ready to look as specific questions from a scientific point of view. As this series unfolds, we will have recourse to use all of the models mentioned—now adding the crucial ingredient of evidence, systematically gathered. In future Updates, the discussion will focus on specific problems and what we can learn about them.

1Jellinek, E.M., Disease Concept of Alcoholism, College and University Press, 1960
2Shuckit, M.A., Drug and Alcohol Abuse: A Clinical Guide to Diagnosis and Treatment, Springer, 2006
3Beresford, T., Psychological Adaptive Mechanisms, Oxford University Press, 2012, Chapter 22

 

Models of Alcoholism: Medical / Physiological Causes

Etiology of Alcohol Abuse or Dependence

Approach

Clinical Intervention

Response/Effect

Clinical Outcome(s)

Medical / Physiological Causes

Medical Illnessi Symptoms, signs, course, treatment "A sick person trying to become well" Disease Model: 1) Hope, 2) Application of clinical science from many disciplines, 3) Self-help programs such as Alcoholics Anonymous, 4) Systematic studies of diagnosis, treatment and prevention
Genetic Conditionii Choice vs. No choice (i.e., congenital predisposition to disease/disorders) "Choice" continues Unclear: Possible early identification/prevention; some genetic influence in some patient groups, not a genetic death sentence
Adaptive Behavior Mechanismsiii Abstinence to improve brain function Restore the brain's neuroadaptive abilities Development of/return to Mature level adaptation; 12 Steps

 

iJellinek, E.M., Disease Concept of Alcoholism, College and University Press, 1960; Valliant, G.E., The Natural History of Alcoholism Revisited, Harvard University Press, 1983
iiShuckit, M.A., Drug and Alcohol Abuse: A Clinical Guide to Diagnosis and Treatment, Springer, 2006
iiiBeresford, T., Psychological Adaptive Mechanisms, Oxford University Press, 2012, Chapter 22

The NCADD Research Update welcomes constructive comments on current installments and suggestions for further topics.

Acknowledgements:

Benjamin Temple, Francisco Maravilla, Chelsea Dize, Ph.D., and Chad Emrick, Ph. D., deserve credit and many thanks for their assistance in developing this Table.

Dr. Beresford would like to thank Ben Temple, Francisco Maravilla and Dr. Chad Emrick for their invaluable review and comment on this series, along with Robert Lindsey, Leah Brock and Greg Muth of NCADD as well as David Lewis, MD and Sara Jo Nixon, PhD, my most esteemed colleagues.

 

Acknowledgements:  Benjamin Temple, Francisco Maravilla, Chelsea Dize, Ph.D., and Chad Emrick, Ph. D., deserve credit and many thanks for their assistance in developing this Table.

 

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Comments 1

Guest - Lisa Chierici on Thursday, 19 April 2018 14:57
Genetics + Environmental Stressors (abuse) + Sociocultural Influences + Choice

I've always know that alcoholism/addiction was much more complicated than common wisdom would have us believe. "Be strong," "Just Say No" and "it's your choice," are common recommendations from both "normies" and those for whom "will power" was all it took. In my case, alcoholism/addiction runs through both my father's and mother's families. Add to that the fact that my father started beating my brother before he was two years old. We all got whipped on the bare bottom with a thin leather belt. My brothers often had bloody, bruised welts on their backsides. These "spankings" were the least of it for my older brother. My dad beat him with his fists as well. My dad was 6'1", 220 lbs of solid muscle, a trained boxer and black belt in Judo. We lived in fear. Add to that the fact that my parents were extremely social and used every excuse for a party. All events had alcohol at the center. All four of us, my three brothers and I, are alcoholic/addicts. Only my youngest brother has maintained sobriety for more than 7 years (He's been sober over 20 yrs). he was also coddled by my mother. He was a premie and needed nursing so my mom grew more attached to him than the rest of us. She protected him as much as possible so he didn't suffer the same, prolonged terror that my older brother suffered.

I'm glad to see that different models of alcoholism have been fleshed out and that research is being done on all of them. Thank you for working to understand this very complex issue.

I've always know that alcoholism/addiction was much more complicated than common wisdom would have us believe. "Be strong," "Just Say No" and "it's your choice," are common recommendations from both "normies" and those for whom "will power" was all it took. In my case, alcoholism/addiction runs through both my father's and mother's families. Add to that the fact that my father started beating my brother before he was two years old. We all got whipped on the bare bottom with a thin leather belt. My brothers often had bloody, bruised welts on their backsides. These "spankings" were the least of it for my older brother. My dad beat him with his fists as well. My dad was 6'1", 220 lbs of solid muscle, a trained boxer and black belt in Judo. We lived in fear. Add to that the fact that my parents were extremely social and used every excuse for a party. All events had alcohol at the center. All four of us, my three brothers and I, are alcoholic/addicts. Only my youngest brother has maintained sobriety for more than 7 years (He's been sober over 20 yrs). he was also coddled by my mother. He was a premie and needed nursing so my mom grew more attached to him than the rest of us. She protected him as much as possible so he didn't suffer the same, prolonged terror that my older brother suffered. I'm glad to see that different models of alcoholism have been fleshed out and that research is being done on all of them. Thank you for working to understand this very complex issue.
Guest
Thursday, 24 May 2018
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