Introducing a compound called CB1 PAM

Introducing a compound called CB1 PAM

The risks associated with the use of opioids and medical marijuana have fueled the search for safer, effective pain medications.

It is known that opioids and medical marijuana are considered effective treatments for chronic pain, but the drugs carry significant risks.

Andrea Hohmann, of Indiana University in Bloomington, and team believe they may have moved one step closer to a potential candidate: a compound called CB1 PAM.

The researchers recently presented their findings at the Society for Neuroscience's 46th annual meeting, held in San Diego, CA.

According to Medical News Today, the researchers used CB1 PAM and it’s use led to long-term pain relief in mice. Importantly, the article notes, the compound did not trigger the "high" associated with marijuana use, and unlike the marijuana compound THC and endocannabinoid breakdown inhibitors, CB1 PAM showed long-term efficacy for preventing pain.

"Our studies show that we can maintain or preserve therapeutic efficacy in ways that we haven't seen with some of the other classes of analgesics that are used in the clinic,” noted Ms. Hohmann. “The most exciting aspect of this research is the potential to produce the same therapeutic benefits as opioid-based pain relievers without side effects like addiction risk or increased tolerance over time."

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